Self Emulsifying Drug Delivery System for Improving Bioavailability

نویسندگان

  • Akanksha Agrawal
  • Arti J. Majumdar
چکیده

Oral route is the most common and convenient route for drug delivery, but some drugs are not given by this route. This route is most common problem is low bioavailability .The various challenges faced by the pharmaceutical scientists leads to the improve bioavailibilityty enhance the approach of self emulsifying drug delivery system. It has gained exposure of their ability to increase solubility and improve the bioavailability of poorly soluble drugs. SEEDS being a lipid based formulations consist oils ,surfactants, solid lipid nanoparticles ,dispersion, emulsion and liposomes .Different type SEEDDS are available in market like as oral drud delivery, Topical delivery, parental drug delivery, ocular & pulmonary drug delivery .Different type of oral dosage forms ae availaalbe in the market like as Self emulsifying capsule,Self emulsifying controlled release pellets, Self emulsifying sustained/controlled release pellets, Self emulsifying solid dispersion. In drug detection and growth solubility has an important role in various step to import high bioavalibilty and to gain required pharmalogical action due o low aqueous solubility,effect the lipophilic drug. Lipophilic drug has shown low bribability when aqueous solubility has low. Keywords-self emulsifying dug delivery system, solubility, bioavailability, dissolution.,Oral drug Delivery,Controlled Drug release.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Development and characterization of rozuvastatin loaded self emulsifying drug delivery system for the effective management of hypolipidemia

The present work was aimed to develop and characterize rosuvastatin loaded self emulsifying drug delivery system for the effective management of hypolipidemia (RSEDDS) for improving bioavailability, to enhance solubility, to prolong residence time and to provide sufficient amount of drug to a target site in a sustained release manner. Self-emulsifying drug delivery system was prepared by simple...

متن کامل

Design, Development and In Vitro Characterization of Self Emulsifying Drug Delivery System for Irbesartan

The objectives of present investigations were to optimize concentration of oil, surfactant and cosurfactant by pseudoternary phase diagrams and to develop a stable formulation of self emulsifying drug delivery system (SEDDS) in order to enhance the dissolution rate of poorly soluble Irbesartan (IBS) by SEDDS. Pseudoternary phase diagrams were constructed to identify the self emulsifying region....

متن کامل

Self Nano Emulsifying Drug Delivery Systems for Oral Delivery of Hydrophobic Drugs

Self-emulsifying drug delivery systems (SNEDDS) are highly in quest due to their innumerable benefits like better portability, improved stability and higher drug loading, coupled with ease and economy of their production. SNEDDS are used to improve the solubility of high lipophilic drugs. SNEDDS are improving the oral bioavailability of limited water-soluble drug compounds. These SNEDDS are iso...

متن کامل

Introducing Self-Nanoemulsifying Drug Delivery System to Increase the Bioavailability of Oral Medications

Due to low cost, ease of administration, and lack need for trained personnel, the oral route is the most convenient and accessible way to design different medicines that could be simply consumed by patients. Regardless of the great benefits of this route, the main challenge in the bioavailability of oral medications is gastrointestinal instability. Nanotechnology is used to improve the solubili...

متن کامل

Development of Solid Self Emulsifying Drug Delivery Systems Containing Efavirenz: in Vitro and in Vivo Evaluation

Efavirenz is a drug with an absorption window. Its oral bioavailability is 40-50%. The aim of this work was to formulate solid self-emulsifying drug delivery system to improve the solubility and bioavailability of efavirenz. Solubility of Efavirenz was determined in various vehicles like oils, surfactants and co surfactants. Which, upon dilution with aqueous media, spontaneously form fine oil i...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016